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A recent study conducted at Mount Sinai School of Medicine in New York suggests that a Chinese botanical drug can help patients manage their food allergies. This new drug may help many allergic patients in the western society and could also assist in curing other conditions such as asthma.

Food allergies have been turning into an increasingly common ailment in the western world. In the US alone, about 5% of the adults and 10% of the children suffer from one allergy or another. Allergies can be very dangerous, as in some cases the allergic individual may have a severe reaction to the allergen and in extreme cases can even go into anaphalactic shock and die. The traditional treatment for food allergies is simple avoidance. In case of failure in avoidance, a liquid antihistamine can be used to stop the allergic reaction and in some cases, epinephrine can be injected.

Dr. Xiu-Min Li from the Mount Sinai hospital recently realized that there are significantly fewer cases of allergies in China than in the United States. She believes that traditional Chinese medicine that is based on plants’ medical properties can be used to cure allergies. Together with a group of researchers she found a food allergy herbal formula (FAHF-2) which produced long term protection against peanut-induced anaphylaxis in mice. Treatment using FAHF-2 protected peanut allergic mice from anaphylaxis for more than 36 weeks after the mice stopped receiving the drug.

“Food allergy is a serious and sometimes fatal condition for which there is no cure,” said Dr. Li. “Approximately 80% of fatal or near-fatal anaphylaxis cases are due to peanut allergy in this country. There is an urgent need for effective therapies to prevent and treat those who suffer from food allergies and FAHF-2 could prove to be a major advancement in this field.”

The new formula may help not only individuals allergic to peanuts but also sufferers from a variety of other ailments. These include allergies to fish, shellfish, and tree nuts as well as severe or persistent asthma. Normally, asthma is treated by inhaled steroids which may cause serious side effects. If this type of steroid is used for long periods of time it may impair growth and cause immune-suppression. Parents of asthmatic children are showing an increasing interest in alternative treatments, with 60% of the children receiving some form of it in the past year.

The FAHF-2 drug has recently entered the human trials stage and is currently being tested at Mount Sinai to evaluate its safety and early efficacy on multiple food allergies including peanut, tree nut, fish, and shellfish.

TFOT has previously brought you several stories of disease cures found in plant sources. One such story described an experiment conducted at the Northwestern University which showed that an antioxidant present in soybeans was able to reduce metastases. More recently we’ve brought you the purple tomatoes that may reduce the chances for cancer developed by researchers from the John Innes Centre in Norwich, U.K.

You can read more on the Chinese botanical drug on the Mount Sinai website.

via Chinese Botanical Drug to Cure Peanut Allergies.

I’ll continue to try to locate the results but please exercise caution and ask many questions before jumping into this kind of study. DO NOT TRY THIS AT HOME. The doctors and researchers are using very measured doses and processes to do this study. This could be dangerous if not fatal to attempt this on your own.

CONCORD, N.H. — One mom says she’d be first in line for a promising treatment that exposes children with peanut allergies to tiny amounts of peanut flour. Another remains fearful, with the painful image of her son’s face blown up beyond recognition still fresh in her mind.

While some parents of children with life-threatening peanut allergies see a glimmer of hope in a recent study suggesting a possible cure, others remain dubious that it will ever change their children’s lives.

“It’s like when we were growing up 20 years ago and we saw the flip phones on ‘Star Trek’ – that was going to be the wave of the future, but we thought that would never happen,” said Eva Stilkey of Raymond, N.H. “It’s great, but those of us who live with the disappointment and the reality of it, you kind of protect yourself. We really do hope it happens someday, but we don’t want to have false hope.”

Earlier this week, scientists announced the findings of a small study that involved giving a handful of highly allergic children tiny amounts of peanut flour daily for more than two years. Gradually, the children became less sensitive, and so far, five show no remaining sign of the allergy.

Larger studies are beginning to see if the treatment works for more people and how long it lasts. But it was big news for the many people who are allergic to peanuts.

Stilkey’s son, Nicholas, who turns five on Friday, was 2 1/2 when a single bite of peanut butter pie sparked a severe reaction.

“We had him spit it out, and when he did, when he lifted his head back up. I couldn’t even recognize him. His face was blown up to a point where there was no separation between his nose or his lips. He was stuffing his hands frantically down his throat trying to breathe,” she said.

Stilkey considers the study participants heroes, but she’s in no hurry to follow in their footsteps.

“I am full of complete admiration for the parents and those children who put themselves through that because I know as a mother, I would be absolutely fearful to try to put Nick through that, just because I’ve seen what happened to him,” she said.

Tamara Leibowitz, who runs a support group for parents of children with food allergies in Portsmouth, N.H., said it would be a leap of faith to subject her son to small doses of what essentially has been considered poison, but “I think we’d jump at the chance.”

“My son would be terrified at the beginning, but he’s been paying attention, too, even at nine years old, and he’s really encouraged by what he sees,” she said, describing her own reaction as “cautiously optimistic.”

In Orange County, Calif., Louise Larsen said she, too, would seek out the treatment if it becomes available.

“Would I put my child through that? Sure, if I sat right next to her, and we went very slowly and it was in a very controlled setting,” said Larsen, whose 12-year-old daughter is allergic to peanuts. But she said she would never be completely convinced that the allergy was gone.

“Even if they did conclude she no longer had any allergy, as her mom, I’m going to send an EpiPen with her until she goes to college,” she said, describing the portable injections used to treat anaphylaxis, a severe allergic reaction marked by swelling of the throat or tongue, hives and breathing trouble.

Another California mom, Lori Fletcher, would be just as eager to try the treatment on her six-year-old son, though she and other parents worry that publicity over the breakthrough would create more misconceptions about food allergies. She doesn’t want people who have heard the news to assume that it means her son now can have “just a little bit” of food containing peanuts. “We still need to be avoiding it,” she said.

But she also found the news inspiring, and plans to use it to promote an upcoming fundraising walk.

“I hope people take from it that if we do raise money, we can get a treatment fairly soon,” said Fletcher of Danville, Calif.

In the meantime, parents said they will remain vigilant, obsessively checking each food label and ensuring their children’s safety at home and school.

“Every time you think you finally have come to a point where you can sit back a little and trust the school has everything in place, you get the phone call that someone has brought this in by mistake,” said Stilkey.

Lori Pelletier-Baker of Concord, N.H., hasn’t faced that situation yet because her four-year-old daughter isn’t in school, but kindergarten is just around the corner.

“It is a constant weight that I think everybody, including Kaleigh, carries on their shoulders,” she said. This week’s breakthrough doesn’t lessen that weight, she said.

“There’s that piece of me that thinks, ‘Wow, that’s so amazing!’ But the reality is that it may take a long time to reach us,” she said. “I’m not going to give up hope, but I know that things aren’t going to change any time soon.”

Copyright © 2009 The Canadian Press. All rights reserved.

via The Canadian Press: Mixed reaction from parents on peanut allergy advance; many remain dubious.

Herbal Remedy Could Halt Peanut Allergy

Tests in mice were successful, and human trials are under way

Posted February 13, 2009

By Steven Reinberg

HealthDay Reporter

FRIDAY, Feb. 13 (HealthDay News) — A new herbal formula based in ancient Chinese medicine may be able to control allergic reactions to peanuts and other foods, researchers from New York City’s Mount Sinai School of Medicine report.

Food allergies are potentially life-threatening for children and adults. Food allergies among children have increased 18 percent since 1997, and in 2007, some 3 million U.S. children had food allergies, according to the National Center for Health Statistics. Currently, there is no treatment for the allergies, so avoidance is the only protection.

“We can reverse the peanut allergic reaction,” said lead researcher Dr. Xiu-Min Li, director of the Center for Chinese Herbal Therapy for Allergy and Asthma at Mount Sinai.

In addition, protection from allergic reactions to peanuts persisted for almost nine months after treatment was stopped, Li said. “The herbal formula can stop peanut allergy and produce a prolonged protection,” she said. “This formula may be effective for human peanut allergy.”

The report was published in the February online edition of The Journal of Allergy and Clinical Immunology.

For the study, Li’s team tested their new herbal remedy, called Food Allergy Herbal Formula (FAHF-2), on mice allergic to peanuts. They found that the formula protected mice from allergic reactions from peanuts.

In fact, FAHF-2 protected the animals from anaphylaxis for more than 36 weeks after treatment was stopped. This is one-quarter of the mouse life span, Li noted.

Li’s team has also shown the formula protects mice against other food allergies including tree nut, fish and shellfish.

Based on these findings, FAHF-2 has been given investigational new drug approval by the U.S. Food and Drug Administration; a human trial started last year.

The trial is testing the safety and effectiveness of the remedy for a variety of food allergies including peanut, tree nut, fish and shellfish, Li said. “The results of the trial have shown that FAHF-2 is safe and well-tolerated,” she noted.

In addition to FAHF-2, Li’s team has developed an herbal formula to treat asthma. That formula is also being tested in human trials, she said.

Dr. David L. Katz, director of the Prevention Research Center at Yale University School of Medicine, said that no matter where it comes from, a cure for peanut allergy would be an important breakthrough.

“This paper suggests that traditional Chinese medicine may offer promising therapy for peanut allergy,” Katz said. “This is less surprising than it may seem.”

First, it is probable that the use of herbs as medical therapy over a span of many centuries would distinguish the helpful from the useless and harmful by a process of trial-and-error, Katz said. Second, most drugs are derived from plants. “So, the actual differences between pharmacotherapy and herbal therapy are differences of degree, not kind,” he said.

When traditional Chinese medicine works, doctors want to know the science of how it works, Katz said. “But for the sake of their patients, conventional practitioners should look past terminology that may make them wince to see the promise of new and potentially effective treatments.”

Allergic reactions to food can range from mild hives to vomiting to difficulty breathing to anaphylaxis, the most severe reaction. Anaphylaxis causes muscles to contract, blood vessels to dilate and fluid to leak from the bloodstream into the tissues. This can result in narrowing of the upper or lower airways, low blood pressure, shock or a combination of these symptoms, and also can lead to a loss of consciousness and even death.

More information

For more information on food allergies, visit the U.S. National Library of Medicine.

via Herbal Remedy Could Halt Peanut Allergy – US News and World Report.